|
KMID : 0361020040470060545
|
|
Korean Journal of Otolaryngology - Head and Neck Surgery
2004 Volume.47 No. 6 p.545 ~ p.545
|
|
|
A Study of Prevalence between allaergic Rhintis and CGR5 GEne Polymorhism Study of a Koarean Population
|
|
이재훈:Lee Jae-Hoon
최태욱:Choi Tae-Wook/오차근:Oh Cha-Kun/박수엽:Park Su-Yeob/윤성원:Yoon Sung-Weon/김정중:Kim Jeong-Joong
|
|
|
Abstract
|
|
|
BACKGROUND AND OBJECTIVES:
CC chemokine receptor (CCR5) is characteristic of the Th 1 phenotype, the receptor of RANTES, MIP-1alphaand MIP-1beta. The receptor of CCR5 delta32 (a 32 bp deletion in the CCR5 gene, mutant type) results in the production of a non-functional receptor. Given the potential importance of CCR5 in allergic inflammation, we hypothesized that individuals carrying the CCR5 delta32 allele would show a reduced prevalence of allergic rhinitis.
SUBJECTS AND METHOD:
Blood samples for genetic analysis were obtained from 187 individuals with allergic rhinitis and from 278 healthy subjects without atopic diseases. Polymerase chain reaction-based assay for the CCR5 gene polymorphism was used for genotyping.
RESULTS:
We could not find the CCR5 delta32 homozygotes and heterozygotes at all in neither of the controls nor allergic rhinitis Korean patients.
CONCLUSION:
Since the CCR5 delta32 allele frequency did not deviate from that in the healthy control population, it is unlikely that this allele influences predisposition to allergic rhinitis in Koreans.
|
|
|
KEYWORD
|
|
|
Receptors CCR5, Perennial allergic rhinitis, Koreans, Polymorphism
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|